ALLERGIC CONTACT DERMATITIS

  • Delayed-Type Hypersensitivity (DTH) is an immune reaction in which memory T-cells play a pivotal role.
    The reaction is antigen specific and causes erythema, oedema and an induration at the site of the antigen injection in immunized animals or humans.


    OVALBUMIN model

    DTH is induced in female Lewis rats by subcutaneous injection of emulsion of ovalbumin/complete Freund's adjuvant.
    One week later, the rats are challenged with an injection of ovalbumin in the pinna ear.

  • Delayed-Type Hypersensitivity (DTH) in Lewis rats

    The DTH reaction is determined by measuring the increase in the pinna ear thickness 24 hours after the ovalbumin challenge.


    OVALBUMIN model
  • Ear swelling induced by ovalbumin challenge is reduced by dexamethasone treatment



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