NERVE FUNCTION
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Sensorimotor deficit is observed under various diseases that affect the nervous system.
SNCV
Sensory nerve conduction velocity is used in the diagnosis of nerve damage or nerve dysfunction. NEUROFIT implements this test to evaluate the neuroprotective properties of compounds.
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Compound testing
Neuro-regenerative drugs are usually tested in this model but other treatments could also be considered. Please feel free to contact us to discuss the feasibility of your study.
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Endpoints
Conduction velocity time course
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Nerve conduction deficit in diabetic rats
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Reduction of nerve conduction velocity similar to that observed in human are observed.
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Sciatic nerve crush
Sciatic nerve crush injury in the mouse is a widely used model for peripheral nerve regeneration.
CMAP
Compound muscle action potential consist in stimulating a nerve fiber and monitoring the response in the muscle.
Dynamic Weight Bearing
The DWB is based on an instrumented floor-cage combined with a video recording to evaluate spontaneous pain.
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Axon calibre / distribution
Nerve morphometry.
STZ (peripheral neuropathy)
Diabetic neuropathy can be studied in rat following streptozotocin administration which induces a rapid and persistent hyperglycaemia.