ALLERGIC CONTACT DERMATITIS

  • Contact dermatitis is an adverse cutaneous reaction resulting from direct contact with an irritant or allergic substance.
    The skin’s reaction is an inflammation-driven process characterized by swollen itchy red rash or rough and dry skin.


    OXAZOLONE model

    Oxazolone is an allergic contact dermatitis inducer resulting in a type I cytokine response and has therefore been used as an animal model for identifying potential anti-inflammatory and immuno-modulating drugs.

  • Animal model of contact dermatitis


    NEUROFIT conducts screening and profiling of drug candidates in oxazolone-induced contact dermatitis.
    Other animal models on inflammatory disorders are also available.


    OXAZOLONE model

  • Dexamethasone

    Ear swelling induced by oxazolone challenge in the rat. Dexamethasone treatment signficantly reduced the reaction.



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  • Apremilast

    Ear swelling induced by oxazolone challenge in the rat (blue bar). Per os treatment with Apremilast markedly reduced the ear inflammation (red bars).


  • Calcipotriol

    Ear swelling induced by oxazolone challenge in the rat (blue bar).Topical application of Calcipotriol markedly reduced the ear inflammation (red bars).


  • Clobetasol

    Ear swelling induced by oxazolone challenge in the rat (blue bar).Topical application of Clobetasol markedly reduced the ear inflammation (red bars).


  • Dimethyl fumarate

    Ear swelling induced by oxazolone challenge in the rat (blue bar). Per os treatment with Dimethyl fumarate markedly reduced the ear inflammation (red bars).


  • Tacrolimus

    Ear swelling induced by oxazolone challenge in the rat (blue bar).Topical application of Tacrolimus markedly reduced the ear inflammation (red bars).


  • Tofacitinib

    Ear swelling induced by oxazolone challenge in the rat (blue bar).Per os treatment with Tofacitinib markedly reduced the ear inflammation (red bars).


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