Rheumatoid arthritis (RA) is a widespread (prevalence 0.5–1%), chronic inflammatory disease and has several pathological features of autoimmune disease.
The disease is characterized by cellular infiltration in synovial tissue, pannus formation, and both cartilage and bone erosion. RA leads to the destruction of cartilage and bone.
Pristane-induced arthritis is a preclinical model of arthritis that exhibits features of human rheumatoid arthritis such as symmetry of inflammation, chronic and relapsing course of disease, infiltration of T cells, and erosive destruction of cartilaginous peripheral joints. Neurofit implemented this model to test the anti-arthritic efficiency of immunomodulatory or anti-inflammatory therapy.
Anti-arthritic therapeutics are usually tested in this model but other treatments could also be considered. Please feel free to contact us to discuss the feasibility of your study.
☐ Paw swelling
Rapid, robust and validated PIA model in Dark-Agouti rats.
Quantitative measure of paw swelling in arthritic rats. Dexamethasone fully prevents the paw swelling symptom of arthritis in rats.
Semi-quantitative scoring of experimental arthritis severity. Dexamethasone fully prevents the appearance of clinical symptoms of arthritis in rats.
Other immune-driven inflammatory models also available :
- Models for Multiple sclerosis such as the Relapsing-Remitting EAE in the rat
- Model for Delayed-type hypersensitivity (DTH): Ovalbumin-induced DTH
- Models for Contact dermatitis: Oxazolone-induced contact dermatitis
- Model for general inflammation: Carrageenan air pouch model
You could also be interested in
Preclinical model of arthritis that exhibits features of human rheumatoid arthritis. Anti-arthritic therapeutics are usually tested in this model.