NEUROMUSCULAR FUNCTION

  • CMAP

    Compound muscle action potential (CMAP) consist in stimulating a nerve fiber and monitoring the response in the muscle. Commonly, CMAP signal is altered in the case of peripheral neuropathies. Neurofit implements this translational test to evaluate the neuroprotective effect of your compounds.

  • Compound testing


    Neuroprotective drugs are usually tested in this model but other treatments could also be considered. Please feel free to contact us to discuss the feasibility of your study.

  • Endpoints


    CMAP time course

  • Validation data

  • Sciatic Nerve Crush injury in mice

  • Model of nerve / axonal regeneration



  • Electrodiagnostic testing



  • Time course of change in the amplitude of CMAP folowing Sciatic Nerve Crush



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    Sensory nerve conduction velocity is used in the diagnosis of nerve damage or nerve dysfunction.

    DWB

    The dynamic weight bearing is based on an instrumented floor-cage combined with a video recording to evaluate spontaneous pain.

  • Sciatic nerve crush / Nerve morphometry

    Sciatic nerve crush injury in the mouse is a widely used model for peripheral nerve regeneration.

    STZ (peripheral neuropathy)

    Diabetic neuropathy can be studied in rat following streptozotocin administration which induces a rapid and persistent hyperglycaemia.