Scientific posters

NEUROFIT is a pre-clinical CRO offering set of in vitro and in vivo screening assays for psychiatry, neurology, multiple sclerosis and pain.
NEUROFIT's repertoire of screening tests is extensive and a full catalogue can be found on THERAPEUTIC AREA or TESTS with reference data.


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Society for Neuroscience 2019

β-Methylamino-L-alanine (L-BMAA) induces neuronal injury via kinase-dependent mechanisms in rat primary neuronal cultures

Cindy Duchemin · Emile Andriambeloson · Stéphanie Wagner

Forum of Neuroscience
FENS 2018

Federation of European Neuroscience Societies.
An inflammation induced by lipopolysaccharide causes the death of neuronal cultures and produces in-vivo brain dysfunction: The preventive effect of dexamethasone

E.Andriambeloson · B.Huyard · E.Poiraud · F.Lauga · C.Neveu and S.Wagner

Society for Neuroscience 2017

Acute and sustained excitoxicity differentially influence riluzole’s neuroprotective effect.

S.Wagner · E.Andriambeloson · C.Neveu

Society for Neuroscience 2017

Cognitive impairment induced by systemic inflammation in mice.

E.Andriambeloson · B.huyard · E.Poiraud · F.Lauga · C.Neveu · S.Wagner

FEPS 2017

Federation of European Physiological Societies.
Dynamic Weight Bearing test for assessing effects of acute intramuscular administration of botulinum neurotoxin type A1 in the rat.

S.Cornet · C.Périer · L.Gorj · S.Wagner · E.Andriambeloson · B.Pouzet · M.Kalinichev

ECNP Congress
2017

Donepezil improves cognitive deficit but not hypermobility induced by cholinergic and glutamatergic antagonists in mice.

S.Wagner · E.Poiraud · B.Huyard · S.O’Connor · E.Andriambeloson

Society for Neuroscience 2016

Stimulus-evoked and spontaneous pain in Complete Freund's adjuvant-induced arthritis in the rat.

S.Wagner · J.Bindler · L.Bourgoin · E.Andriambeloson

Society for Neuroscience 2016

Mitoxantrone prevents disease relapse in a rat model of multiple sclerosis.

E.Andriambeloson · J.Bindler · C.Neveu · L.Bourgoin · L.Gorj · B.huyard · N.Kadouci · F.Lauga · E.Poiraud · S.Wagner

iForum 2016

Compounds with different pharmacological profiles enhance the neurite outgrowth in Human iPSC-derived neurons.

C.Duchemin · E.Andriambeloson · S.Wagner

Society for Neuroscience 2015

The antioxidant N-acetyl-L-cysteine exerts strong neuroprotective effects in both in-vitro and in-vivo models of Parkinson's disease.

E.Andriambeloson · C.Duchemin · N.Kadouci · F.Lauga · E.Poiraud · B.Huyard · S.Wagner

Society for Neuroscience 2015

The effect of immunosuppressive and immunomodulatory drugs in a cellular model of brain inflammation: involvement of nitric oxide-mediated neuronal death.

C.Duchemin · E.Andriambeloson · S.Wagner

Society for Neuroscience 2015

Animal model of cognitive dysfunction responding to ADHD therapies.

E.Andriambeloson · E.Poiraud · B.Huyard · L.Gorj · S.O'Connor · S.Wagner

Neuroscience 2014

The novel anxiolytic compound BNC210 is a negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor.

S.M.O'Connor · A.A.Grishin · E.Poiraud · B.Huyard · C.Coles · Y.Kolev · S.Wagner · E.Andriambeloson

European Federation for Medicinal Chemistry - ISMC 2014

A non-sedating dose of diazepam improves symptoms of panic anxiety disorder in the rat.

E.Andriambeloson · E.Poiraud · J.Bindler · B.Huyard · S.Wagner

ANS 2013

BNC375, a novel positive allosteric modulator of th alpha 7 nicotinic acetylcholine receptor, exhibits cognitive enhancement in rodent behavioural models.

A.A.Grishin · P.Kolesik · C.Coles · Y.Kolev · S.Wagner · B.Huyard · E.Andriambeloson · A.Harvey · S.M.O'Connor

Society for Neuroscience 2013

Subchronic donepezil prevents Amyloid-β-induced memory disruption in the rat.

S.Wagner · E.Poiraud · E.Andriambeloson

Society for Neuroscience 2012

Methyllycaconitine and scopolamine-induced cognitive dysfunction: differential reversal effect of cognitive-enhancing drugs.

E.Andriambeloson · B.Huyard · E.Poiraud · S.Wagner

Society for Neuroscience 2012

Evaluation of dynamic weight bearing (gait) following unilateral sciatic nerve crush in the mouse.

S.Wagner · L.Gorj · J.Bindler · E.Poiraud · N.Kadouci · E.Andriambeloson

Society for Neuroscience 2012

Characterization of novel type I positive allosteric modulators of the α7 nicotinic acetylcholine receptor.

A.Harvey · P.Kolesik · A.Grishin · C.Coles · D.Paul · B.Huyard · S.Wagner · E.Andriambeloson · L.Schaeffer · B.Giethlen · S.O’Connor

Society for Neuroscience 2012

Three novel type II positive allosteric modulators of the α7 nAChR demonstrate safe, effective cognitive enhancement in mice and rats.

S.O'Connor · E.Andriambeloson · C.Coles · B.Huyard · A.Grishin · P.Kolesik · Y.Kolev · S.Wagner · A.Harvey

Society for Neuroscience 2011

Dexamethasone markedly reduces the clinical deficit in relapsing-remitting experimental autoimmune encephalomyelitis in the rat.

S.Wagner · J.Bindler · E.Andriambeloson

Baden-Baden 2011

A multicomponent medication enhances cognitive function in vivo.

K.Roeska · S.Wagner · E.Andriambeloson · Y.Burmeister · B.Seilheimer

ECNP Paris 2011

The phospholipase C inhibitors U73122, D609 and Edelfosine inhibit the activity of the novel anxiolytic and antidepressant compound BNC210.

S.O'Connor · S.Wagner · G.Kremmidiotis · E.Andriambeloson

ECNP Paris 2011

Evaluation of the novel anxiolytic BNC210 in a rat model of cholecystokinin-induced panic.

S.O'Connor · B.Huyard · S.Wagner · G.Kremmidiotis · E.Andriambeloson

Neuroscience 2011

The novel compound BNC210 partially reduces Panic Symptom Scale scores in a model of CCK-4 induced panic in healthy volunteers.

S.O'Connor · E.Doolin · N.Pross N · D.Metzger · N.Guichard · E.Andriambeloson · G.Kremmidioti · P.Danjou

Society for Neuroscience 2009

Kv1.3 ion channel blockers as novel, oral therapies for Multiple Sclerosis.

J.Mould · E.Andriambeloson · J.Chaplin · C.Coles · A.Harvey · D.Paul · M.Staykova · J.Baell · B.Flynn

Society for Neuroscience 2009

The novel anxiolytic compound BNC210 reduces stress on the EPM in pre-stressed rats and exhibits an antidepressant effect in the rat forced Swim test.

S.O'Connor · E.Andriambeloson · B.Huyard · S.Wagner · B.Sleebs · C.Bui · I.Street · G.Kremmidiotis

European Behavioural Pharmacology Society 2008

BNC-210: a novel compound with potent anxiolytic activity.

E.Andriambeloson · S.Wagner · B.Huyard · B.Sleebs · N.Quasi · C.Bui · S.O'Connor · I.Street

ECNP Barcelona 2008

BNC210 is a novel, fast acting compound with potent anxiolytic activity and no side effects.

S.O'Connor · B.Huyard · S.Wagner · B.Sleebs · C.Bui · G.Kremmidiotis · I.Street · B.Flynn

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