PERIPHERAL NEUROPATHIES

  • Peripheral neuropathy is the result of damages of the peripheral nervous system. These disorders can be caused either by a trauma or diseases as for example diabetes.
    NEUROFIT proposes animal and cellular models useful for the evaluation of the neuroprotective activity of your coumpounds.


    TAXOL : model of chemotherapy induced neuropathy

    Taxol is widely used as an antimitotic drug for treating various cancers. However, its employment is often limited by their neurotoxicity, including peripheral neuropathy.
    Neurofit developed this model to assess the neuroprotective properties of compounds aiming to counteract chemotherapy side effects.

  • Compound testing


    Neuroprotectant are usually tested in this model but other treatments could also be considered. Please feel free to contact us to discuss the feasibility of your study.

  • Endpoints


    ☐ Neuronal survival dose response curve (phosphatase acid activity)
    ☐ Neuronal death dose response curve (LDH activity)
    ☐ Neurite network measure (immunolabelling)

  • Phosphatase acid
  • extracellular LDH

  • Neurite network
  • Taxol induces cell death and destruction of neurite network in sensory neurons and Schwann cells co-culture from rat embryos. NGF at 5 ng/ml is able to protect neurons against the cisplatin damage.


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  • Basal condition

    Sensory neurons and Schwann cells co-culture from rat embryos.
    Purified sensory neurons culture from rat embryos or from adult rat.

  • Cisplatin treatment

    Peripheral neuropathy is the result of damages of the peripheral nervous system induced by insult such as the neurotoxicity of cisplatine.

    Vincristine treatment

    Peripheral neuropathy is the result of damages of the peripheral nervous system induced by insult such as the neurotoxicity of vincristine.