Novel Object Recognition

  • Presentation


    The object recognition task in rodents is considered a test for evaluating working memory in rodents.

    It is based on the spontaneous exploration of novel and familiar objects. Naive animals will spend more time exploring a novel object than a familiar one. When used in conjunction with pharmacological tools such as scopolamine that induces cognitive deficit (reduction in the recognition index), it becomes a useful model for screening compounds with memory enhancing properties.

  • Compound testing


    Cognitive enhancers or disease modifiers are usually tested in this test but other treatments could also be considered. Please feel free to contact us to discuss the feasibility of your study.

  • Endpoints


    Recognition index (time spent exploring the novel object)
SCOPOLAMINE model

  • Reversal of Scopolamine-induced cognitive deficit in the novel object recognition assay by Nicotine.
    Scopolamine and/or Nicotine are given at the beginning of the acquisition trial. Retention trial is performed 30 min after the acquisition trial.

    Recognition index: proportion of time spent exploring the novel object.


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