Cinnamaldehyde ameliorates
brain inflammation-related cognitive deficit


Newsletter # 100


In vivo studies


Cinnamon is commonly prescribed in traditional Chinese medicine to treat various disease conditions. Cinnamaldehyde is the major constituent (92%) of Cinnamon bark essential oil and is reported with multiple properties such as anti-diabetic, anti-cancer, anti-microbial, antioxidant and anti-inflammatory. While the effect of cinnamaldehyde on the human brain is lacking, a small clinical trial demonstrated a therapeutic activity in patients with type II diabetes 1 , a condition which can be associated with an increased risk of Alzheimer's disease 2.

Preclinical data from Neurofit indicated that 1 week treatment with cinnamaldehyde is sufficient to show therapeutic benefits in a mouse model of inflammation-induced cognitive deficit. This finding suggests that cinnamaldehyde not only interferes with brain oxidative stress and inflammatory processes but could also potentially lead to a real benefit for patients under such a type of pathological condition.



If you are interested in these models and would like to learn more about them or other models and assays available at NEUROFIT, please visit our website : THERAPEUTIC AREA or TESTS sections

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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