translational model of cognitive deficits
Newsletter # 68
This method shows several advantages:
■ it reduces systemic exposure,
■ it facilitates chronic treatment protocols,
■ It is already employed in various medical conditions or diseases.
Intranasal Donepezil administration reverses cognitive deficit induced by Scopolamine
Here we provide data that proves the efficiency of intranasal administration approach in a cognitive deficit model routinely used at NEUROFIT ■Donepezil treatment through intranasal administration clearly reverses scopolamine-induced deficit with a marked dose-effect.
■The results are reliable to the results previously obtained with Donepezil in oral administration.
■Intranasal administration is a valuable alternative to ICV approach, acute or repeated, with or without pump.