Newsletter # 14
Animal models
In this test, the integrity of muscle function is assessed by the time taken for the mouse to catch a wire in its hindpaws whilst hanging from its forepaws. The myorelaxing effect of diazepam was detected far below the dose that impaired performance on the rotarod or the open-field which indicates the high sensitivity of the wire-hanging test for distinguishing muscle weakness/relaxation or ataxia.
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Wire-hanging test
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Mean time score (left panel) and percentage of success (right panel) of diazepam-treated mice over 3 successive trials in the wire-hanging test.
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Open Field test
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Rotarod test
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Performance of diazepam-treated mice in the open-field test (left panel) and in the rotarod test (right panel)
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