ALZHEIMER'S DISEASE

  • Alzheimer’s disease is the most common age-related neurodegenerative disorder, characterized by the progressive degeneration of neuronal populations and the simultaneous loss of memory and cognitive functions.Aged mice naturally develop cognitive deficits and ultimately Alzheimer’s symptoms.


    AGED MICE model

    Among all the models which focus on one aspect of the disease, aged mice is probably the most representative of the human disease. In that sense, it is one of the most powerful model to test multiple pathways therapeutics.

  • Compound testing


    Cognitive enhancers and disease modifiers are usually tested in this model but other treatments could also be considered. Please feel free to contact us to discuss the feasibility of your study.
  • Endpoints


    Percentage of alternation in the T-Maze (memory performance)
  • T-MAZE Continuous Alternation Task (T-CAT) in mice



  • Nicotine - Donepezil :

    Reversion of Aging-related cognitive deficit in the T-Maze alternation task in the mouse




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