Experimental Autoimmune Encephalomyelitis (EAE) in Lewis rat

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• Presentation

  
  

  EAE is a commonly used animal model which shares some degree of similarities with human multiple sclerosis (MS). EAE is induced by CNS antigens such myelin basic protein (MBP) which activates autoreactive T-cells responsible for CNS inflammation and demyelination. Within 10 days after the immunization with MBP of susceptible Lewis rats they develop a progressive weight loss and paralysis that can be assessed using semi-quantitative neurological scoring system.

• Compound testing

  
  Effect of subchronic or chronic treatment of rats (typically starting before the appearance of first symptom) on:
  
  neurological score until complete recovery
  body weight

• Endpoints

  
  Scoring