PARKINSON'S disease

  • Parkinson’s disease (PD) is a neurodegenerative disorder featured by the loss of dopaminergic neurons of the substantia nigra.
    The primary motor symptoms of patients with PD are muscular rigidity, akinesia-bradykinesia and resting tremor.


    Haldol (catalepsy)

    Catalepsy is a well-known symptom of Parkinson's disease. It is characterized by muscle rigidity and fixity of posture for a prolonged period of time (akinesia).
    Neuroleptic drugs such as haloperidol induces catalepsy and are thus used as a model for screening of new compounds that could reverse catalepsy and by the way improve the symptom of Parkinson’s disease.

  • Compound testing


    Anti-parkinsonian drugs are usually tested in this model but other treatments could also be considered. Please feel free to contact us to discuss the feasibility of your study.
  • Endpoints


    Haloperidol-induced catalepsy
    Akinesic symptoms of PD
  • The degree of inhibition / reversion of haloperidol-induced catalepsy is used to measure the potential effect of new drugs on akinesic symptoms of PD.




  • Graph A :

    Time course of Haloperidol-induced catalepsy in the mouse.
    Treatment with CSC markedly reduces haloperidol-induced catalepsy.



  • Graph B :

    Reduction of haloperidol-induced catalepsy by CSC during the stable phase (180-270min).


You could also be interested in