PERIPHERAL NEUROPATHIES

  • Peripheral neuropathy is the result of damages of the peripheral nervous system. These troubles can be caused either by a trauma or diseases as for example diabetes.
    NEUROFIT proposes animal and cellular models able to evaluate the neuroprotective activity of your coumpounds.


    STREPTOZOTOCIN (STZ)

    Diabetic neuropathy can be studied in rat following streptozotocin administration which induces a rapid and persistent hyperglycaemia.
    As in diabetic patients, the peripheral neuropathy in this model is characterized by reduced nerve conduction and loss of sensation as a result of skin denervation.
    This model is used to assess the neuroprotective potential of test compounds against diabetic neuropathy.




  • Skin denervation in diabetic rats


  • Transverse section of skin

  • Loss of intra-epidermal nerve fibers

  • Nerve conduction deficit in diabetic rats


    Loss of intra-epidermal nerve fibers







  • After a first painful phase, severe loss of intra-epidermal nerve fibers (IENF) in the skin hindpaw and reduction of nerve conduction velocity similar to that observed in human are observed.



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  • IENF

    The degeneration of intra-epidermal nerve fibers can be monitored and quantified in various animal models of peripheral neuropathy.


    Paw pressure

    The paw pressure test consists in applying a uniformly increasing mechanical pressure on the animal paw.

  • SNCV

    Sensory nerve conduction velocity is used in the diagnosis of nerve damage or nerve dysfunction.