RHEUMATOID ARTHRITIS

  • Rheumatoid arthritis (RA) is a widespread (prevalence 0.5–1%), chronic inflammatory disease and has several pathological features of autoimmune disease.
    The disease is characterized by cellular infiltration in synovial tissue, pannus formation, and both cartilage and bone erosion. RA leads to the destruction of cartilage and bone.


    PRISTANE model

    Pristane-induced arthritis is a preclinical model of arthritis that exhibits features of human rheumatoid arthritis such as symmetry of inflammation, chronic and relapsing course of disease, infiltration of T cells, and erosive destruction of cartilaginous peripheral joints. Neurofit implemented this model to test the anti-arthritic efficiency of immunomodulatory or anti-inflammatory therapy.

  • Rapid, robust and validated PIA model in Dark-Agouti rats.

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    Preclinical model of arthritis that exhibits features of human rheumatoid arthritis. Anti-arthritic therapeutics are usually tested in this model.