neurofit@neurofit.com

for CNS and PNS disorders

+33(0)3 88 65 16 06

Validated in vitro and in vivo disease and safety models for drug screening

ANIMAL / BEHAVIOURAL TEST

  • Mice and rats are the most commonly used vertebrate species, popular because of their availability, size, low cost, ease of handling, and fast reproduction rate. They are widely considered to be the prime model of inherited human disease and share 99% of their genes with humans. Behavioral measures are used to detect or measure changes in CNS and PNS functions that may be produced by induced diseases, neural injury, genetic modification or exposure to various drugs and treatments.


    PAIN / INFLAMMATION

    NEUROFIT implements different models and tests to evaluate compounds acting on different types of pain.
    Feel free to contact our experts to discuss about the most relevant test you could apply for your studies.


  • The animal is placed on a heated-plate to measure his thermal pain reflexes which are characterized either by withdrawal of the paw or by licking.


  • Imbalance weight distribution in freely moving animal.


  • The paw pressure test consists in applying a uniformly increasing mechanical pressure on the animal paw. This pressure induces pain leading to an escape reaction.


  • The tail flick test is a thermal hyperalgesia test in which the tail of the animal is subjected to a heat source. Once the animal feels uncomfortable, he removes spontaneously the tail.