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for CNS and PNS disorders

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Validated in vitro and in vivo disease and safety models for drug screening

PARKINSON'S DISEASE

  • Parkinson’s disease (PD) is a neurodegenerative disorder featured by the loss of dopaminergic neurons of the substantia nigra. The primary motor symptoms of patients with PD are muscular rigidity, akinesia-bradykinesia and resting tremor. In rodents, neuroleptic drugs such as haloperidol induce catalepsy characterized by muscular rigidity and behavioral immobility.