SCHIZOPHRENIA
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Schizophrenia is a neurodegenerative disorder characterized by various symptoms such as disturbances in information processing and cognitive impairment. Among the characteristics of this disease, NEUROFIT proposes models inducing cognitive disturbances (poor working memory, concentration troubles…) and hyperactivity (agitation).
D-amphetamine
D-amphetamine enhances the release of dopamine in the central nervous system (CNS) and induces locomotor activation. Developing reliable, predictive animal models for complex psychiatric disorders, such as schizophrenia, is essential to increase our understanding of the neurobiological basis of the disorder and for the development of novel drugs.
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Compound testing
Antipsychotic drugs are usually tested in this model but other treatments could also be considered. Please feel free to contact us to discuss the feasibility of your study.
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Endpoints
☐ Hyperactivity in open field
D-amphetamine: hyperactivity in Open-Field
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Travelled distance /5 min. -
Total travelled distance
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T-Maze
The T-Maze continuous alternation task is among the method implemented to evaluate the spatial exploratory performance in mice.
Open-Field
Locomotor hyperactivity is a widely used method for the screening of antipsychotic drug candidates.
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Phencyclidine
Phencyclidine is a NMDA receptor antagonist often used to produce schizophrenia-like symptoms in humans.
MK-801
NMDA receptor antagonist often used to produce cognitive dysfunction.