Animal model of inflammation-induced cognitive decline

  • Alzheimer’s disease is the most common age-related neurodegenerative disorder, characterized by the progressive degeneration of neuronal populations and the simultaneous loss of memory and cognitive functions.

    Translational in vivo model of inflammation-induced cognitive deficit

    NEUROFIT offers a translational in vivo model of inflammation-induced cognitive deficit. Inflammation is produced in mice by a single administration of a non-septic dose of LPS.
    The model has proved to be useful in demonstrating the clinical effect of drugs or compounds of different mechanisms.

  • Compound testing

    This model offers various possibilities of compound testing such as anti-inflammatory drugs, cognitive enhancers and/or disease modifiers… As this is a non-exhaustive list, please feel free to contact us in order to discuss our possibilities of interaction.
  • Endpoints

    Percentage of continuous and spontaneous alternations in the T-Maze (cognitive performance)
  • An amelioration of the cognitive function in LPS-mice by the administration of drugs used in humans for the treatment of Alzheimer's disease :

    A lower alternation score represents a lower cognitive performance.
    CSA : Continuous and Spontaneous Alternation.

  • *** , statistically significant as compared to the Placebo condition

    Memantine : Alzheimer's disease medication acting on the glutamatergic system by blocking NMDA receptors.

  • *, *** , statistically significant as compared to the Placebo condition

    Ibuprofen : Anti-inflammatory drug. People treated with Ibuprofen for inflammatory conditions are reported to have lower rates of Alzheimer's disease.

  • **, *** , statistically significant as compared to the Placebo condition

    Donepezil : (Aricept) is a centrally active small molecule used in the treatment of Alzheimer’s disease and different cognitive disorders.

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