Animal model of inflammation-induced cognitive decline
Alzheimer’s disease is the most common age-related neurodegenerative disorder, characterized by the progressive degeneration of neuronal populations and the simultaneous loss of memory and cognitive functions.
Translational in vivo model of inflammation-induced cognitive deficit
NEUROFIT offers a translational in vivo model of inflammation-induced cognitive deficit. Inflammation is produced in mice by single administration of a non-septic dose of LPS.
The model has proved to be useful in demonstrating the clinical effect of drugs or compounds of different mechanisms.
This model offers various possibilities of compound testing such as anti-inflammatory drugs, cognitive enhancers or disease modifiers… As this is a non-exhaustive list, please feel free to contact us in order to discuss our possibilities of interaction.
☐ Percentage of continuous and spontaneous alternation in the T-Maze (cognitive performance)
Amelioration of the cognitive function of LPS-mice by drugs used in humans for the treatment of Alzheimer's disease :
A lower alternation score represents lower cognitive performance.
CSA : Continuous and Spontaneous Alternation.
*** , statistically significant as compared to the Placebo condition
Memantine :Alzheimer's disease medication acting on the glutamatergic system by blocking NMDA receptors.
*, *** , statistically significant as compared to the Placebo condition
Ibuprofen :Anti-inflammatory drug. People treated with Ibuprofen for inflammatory conditions are reported to have lower rates of Alzheimer's disease.
**, *** , statistically significant as compared to the Placebo condition
Donepezil :(Aricept) is a centrally active small molecule used in the treatment of Alzheimer’s disease and different cognitive disorders.
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