neurofit@neurofit.com

for CNS and PNS disorders

+33(0)3 88 65 16 06

Validated in vitro and in vivo disease and safety models for drug screening

ANIMAL / BEHAVIOURAL TEST

  • Mice and rats are the most commonly used vertebrate species, popular because of their availability, size, low cost, ease of handling, and fast reproduction rate. They are widely considered to be the prime model of inherited human disease and share 99% of their genes with humans. Behavioral measures are used to detect or measure changes in CNS and PNS functions that may be produced by induced diseases, neural injury, genetic modification or exposure to various drugs and treatments.


    ANXIETY / DEPRESSION

    NEUROFIT provides different tests to evaluate the efficacy of your compounds. As each test implying anxiety and depression assessment is specific, we attach a great importance to the prior discussion to propose you the most relevant solution to answer to your question.


  • The Marble Burying test is used to record the number of marbles buried by mice placed in a novel environment.


  • Animals placed in a container filled with water show periods of increased swimming activity and periods of relative immobility.


  • The EPM situation rests on the conflict between the innate tendencies of rodents to explore novel environments and avoid open and brightly lit areas.


  • The Light-Dark paradigm in mice is based on a conflict between the innate aversion to brightly illuminated areas and the spontaneous exploratory activity.