neurofit@neurofit.com

for CNS and PNS disorders

+33(0)3 88 65 16 06

Validated in vitro and in vivo disease and safety models for drug screening

PERIPHERAL NEUROPATHIES

  • Peripheral neuropathy is the result of damages of the peripheral nervous system. These troubles can be caused either by a trauma or diseases as for example diabetes.
    NEUROFIT proposes animal and cellular models able to evaluate the neuroprotective activity of your coumpounds.


    CISPLATIN : model of chemotherapy induced neuropathy

    Cisplatin is widely used as an antimitotic drug for treating various cancers. However, its employment is often limited by their neurotoxicity.
    Neurofit developed this model to assess the neuroprotective properties of compounds aiming to counteract chemotherapy side effects.



    • Purified cultures of sensory neurons :
      Cisplatin induced cell death in sensory neurons.
      At each dose of cisplatin, NGF at 5 ng/ml is able to protect neurons against the ciplatin damage.

    • Co-cultures of sensory neurons and Schwann cells :
      Cisplatin induces cell death in a dose dependant manner.
      At each dose tested, NGF at 5 ng/ml is able to protect neurons against ciplatin damage.

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  • Viability and survival test

    Purified cultures of sensory neurons or co-cultures from sensory neurons and Schwann cells are injured by chemotherapeutic drugs.

  • Vincristine

    Model of chemotherapy induced neuropathy, the result of damages of the peripheral nervous system.


    Taxol

    Model of chemotherapy induced neuropathy, the result of damages of the peripheral nervous system.