T-maze Continuous Alternation Task (T-CAT) in the mouse

Newsletter # 09

Animal models

The T-maze continuous alternation task (T-CAT) is among the method implemented to evaluate the spatial exploratory performance in mice. The procedure relies on the animal’s natural behaviour to explore novelty and thus alternate between right and left arms.
When used in conjunction with pharmacological tools such as scopolamine, the system allows to induce memory deficit (reduction in the number of alternation) useful as model for screening compounds with cognitive enhancing properties such as nicotine or donepezil.

NEUROFIT is a Contract Research Organisation (CRO) specialising in the evaluation of treatments for peripheral and central nervous system disorders. NEUROFIT offers a long list of in vivo and in vitro validated methods and disease models for drug screening.

  • Reversion of scopolamine-induced deficit by Nicotine in Swiss mice.

  • Reversion of scopolamine-induced deficit by Donepezil in Swiss mice.

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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