Correlation with Preclinical Evidence
Newsletter # 109
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Animal models
Preview: Ibuprofen, Indomethacin, and Sulindac are NSAIDs reported to decrease the risk of AD
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The graphs illustrate mice's cognitive performance in a T-maze, a common test for assessing rodent cognitive behavior. The reduced spontaneous alternation in rodents can be interpreted as a form of memory and cognitive impairment, as the mice are not effectively recalling and alternating between choices.
LPS injection induces brain inflammation, leading to cognitive deficits as evidenced by reduced spontaneous alternations (white vs red column).
NSAID administration, particularly with Ibuprofen, Indomethacin, and Sulindac, improves spontaneous alternation in LPS-treated mice (red vs brown, blue, or green columns), enhancing cognitive ability. This supports the potential of NSAIDs in mitigating brain inflammation and associated cognitive impairment.
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References: 1 : Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid β42 Production by Direct Modulation of γ-Secretase Activity: https://doi.org/10.1074/jbc.M303592200
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