Deciphering the Neuroprotective Benefit of NSAIDs
Correlation with Preclinical Evidence

Newsletter # 109



Animal models

Preview: Ibuprofen, Indomethacin, and Sulindac are NSAIDs reported to decrease the risk of AD

Nonsteroidal anti-inflammatory drugs (NSAIDs), known for their anti-inflammatory properties, are widely used to alleviate pain and reduce inflammation in various conditions. Numerous meta-analyses consistently link NSAID use to a reduced risk of Alzheimer's disease (AD). In AD, brain inflammation caused by beta-amyloid plaques and neurofibrillary tangles plays a significant role in disease progression. NSAIDs, besides their anti-inflammatory effects, may directly hinder the formation of beta-amyloid plaques 1 , influencing the disease's course. Specific NSAIDs like Ibuprofen, Indomethacin, and Sulindac are identified as potentially beneficial for AD.


Preclinical data from Neurofit suggests that these NSAIDs interfere with brain inflammation, providing protection against cognitive impairment. These findings, supported by cross-sectional studies, indicate a protective effect against AD risk among NSAID users, supporting the idea that inflammation is a key factor in AD pathophysiology.


  • The graphs illustrate mice's cognitive performance in a T-maze, a common test for assessing rodent cognitive behavior. The reduced spontaneous alternation in rodents can be interpreted as a form of memory and cognitive impairment, as the mice are not effectively recalling and alternating between choices.
    LPS injection induces brain inflammation, leading to cognitive deficits as evidenced by reduced spontaneous alternations (white vs red column).
    NSAID administration, particularly with Ibuprofen, Indomethacin, and Sulindac, improves spontaneous alternation in LPS-treated mice (red vs brown, blue, or green columns), enhancing cognitive ability. This supports the potential of NSAIDs in mitigating brain inflammation and associated cognitive impairment.

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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