Animal model of Relapsing-Remitting Multiple Sclerosis
(Relapsing-Remitting experimental autoimmune encephalomyelitis in the rat)

Newsletter # 19

Animal models

Multiple sclerosis (MS), an inflammatory, autoimmune and demyelinating disease of the central nervous system, affects about 2.5 million people worldwide. Relapsing-remitting MS (RRMS) is the most common disease course at the time of diagnosis. Approximately 85-90% of individuals with MS are initially diagnosed with RRMS. MS is studied in the animal model experimental autoimmune encephalomyelitis (EAE). However, very limited data are available in the literature about EAE model that closely mimics the clinical symptoms of RRMS.

NEUROFIT offers a validated and robust rat model of EAE with periods of remission and relapse, as seen in the human disease.

  • This model shows a severe clinical score (complete paralysis) and favorably responds to anti-inflammatory / immunosuppressant drug such as dexamethasone

  • Clinical score

  • Neurological scoring system :

    0 no abnormality
    0.5 distal weakness of the tail
    1 complete weakness of the tail
    2 mild weakness in one or two hindlimbs
    3 moderate paraparesia of one or two hindlimbs
    4 severe paraparesia with incontinence
    5 total paraplegia

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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