DONEPEZIL

Newsletter # 25



Animal and cellular models


DONEPEZIL:
Neurotrophic and cognitive-enhancing drug

NEUROFIT is a Contract Research Organisation (CRO) specialising in the evaluation of treatments for peripheral and central nervous system disorders.
NEUROFIT offers a long list of in vivo and in vitro validated methods and disease models for drug screening.

  • Neurotrophic support of donepezil in cortical neurons



  • Donepezil: Neurotrophic effect on primary cortical neurons culture

  • Cognitive / memory enhancing effect of Donepezil in different in-vivo assays


  • Donepezil: Reversion of Aging-related cognitive deficit in the T-Maze alternation task in the mouse

  • Donepezil: Reversion of MK-801-induced cognitive deficit in the T-Maze alternation task in the mouse


  • Donepezil: Reversion of Scopolamine-induced cognitive deficit in the T-Maze alternation task in the mouse

  • Donepezil: Reversion of Methyllycaconitine-induced cognitive deficit in the T-Maze alternation task in the mouse



  • Donepezil: Reversion of natural forgetting in the Object Recognition test in the rat



  • Donepezil: Reversion of Scopolamine-induced cognitive deficit in the Object Recognition test in the rat


  • Donepezil: Reversion of Scopolamine-induced cognitive deficit in the Passive avoidance test in the rat



NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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