nicotine and donepezil in the T-maze assay
Newsletter # 46
In this assay, a single trial (10 min. at most) is sufficient to evaluate the ability of acute treatment (15-60 min. prior the trial) to reverse the MK-801-induced cognitive deficits.
Reversion of MK-801-induced deficit by nicotine and donepezil. The T-maze continuous alternation task is used to evaluate spatial exploratory performance and working memory in mice.
* : significantly different as compared to MK-801 / Vehicle group;
# : significantly different as compared to Saline / Vehicle group.
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