Reversal of MK-801-induced cognitive dysfunction by
nicotine and donepezil in the T-maze assay


Newsletter # 46



Animal models


T-maze Continuous Alternation Task in the mouse using MK-801 to induce cognitive deficits.

NMDA Receptor Antagonists such as dizocilpine (MK-801) are often used to produce cognitive dysfunctions in different screening assays. Most of these assays however are based on two sessions (training session(s) followed by testing session) which markedly increase the turnaround time (and thus the cost) for the assay.


NEUROFIT proposes a cost-effective MK-801 based screening assay in the mouse T-maze alternation that is responsive to memory / learning enhancer drugs such as nicotine or donepezil. The T-maze model is also fully validated for scopolamine-induced cognitive deficits.

In this assay, a single trial (10 min. at most) is sufficient to evaluate the ability of acute treatment (15-60 min. prior the trial) to reverse the MK-801-induced cognitive deficits.

  • Reversion of MK-801-induced deficit by nicotine and donepezil.
    The T-maze continuous alternation task is used to evaluate spatial exploratory performance and working memory in mice.

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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