A functional model of motor unit Rat nerve - Human muscle coculture

Newsletter # 48



Cellular models

NEUROFIT provides you its unique expertise in the nerve-muscle coculture. In this model, motor neurons and muscle fibers are dependent on each other as the motor unit formation and maintenance depends on continuous trophic, electrical and mechanical cross-talk between muscle and motor nerve.

This unique expertise of NEUROFIT allows us to observe motor neuron –dependent myocontraction and thus evaluate the ability of compounds to improve spinal motor neurons functionality. This model could be used to evaluate neurotrophic activity and more generally therapeutics for neuromuscular diseases.

  • BDNF / Insuline

    BDNF at 10 ng/mL and Insulin at 10 µg/mL increase the surface of skeletal muscle innervated by an efficient rat spinal cord-human muscle coupling.

    Possible endpoints:

    - innervation rate
    - innervation area
    - muscle extracts

  • Movies

    This picture represents 3 innervated muscle fibers bundles on muscle derived cells monolayer.



NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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