Glutamate excitotoxicity

Newsletter # 51



Cellular models

Glutamate excitotoxicity is an important mechanism of neuronal death in a wide range of neurological disorders. Stroke, Amyotrophic lateral sclerosis (ALS) and Alzheimer's disease are few examples of pathologies where glutamate excitotoxicity is known to play a role.


NEUROFIT implements glutamate-induced excitotoxicity in primary cultures of cortical neurons in order to evaluate the potential neuroprotective effect of new compounds.



  • Neurotoxicity of glutamate as assessed by the extracellular release of LDH and the neuroprotective effect of increasing doses of MK-801.

    **, *** statistically significant as compared to the Vehicle / glutamate condition



  • Reduced neuronal viability in response to acute glutamate intoxication and the neuroprotective effect of increasing doses of MK-801.

    *** statistically significant as compared to the Vehicle / glutamate condition




  • Destruction of the neuronal network induced by glutamate and the neuroprotective effect of increasing doses of MK-801.

    **, *** statistically significant as compared to the Vehicle / glutamate condition



NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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