Reversal of MK-801-induced cognitive dysfunction by
nicotine and donepezil in the T-maze assay

Newsletter # 12

Animal models

Welcome to our March Newsletter which presents the T-maze Continuous Alternation Task in the mouse, using MK-801 to induce cognitive deficits.
NMDA Receptor Antagonists such as dizocilpine (MK-801) are often used to produce cognitive dysfunctions in different screening assays. Most of these assays however are based on two sessions (training session(s) followed by testing session) which markedly increase the turnaround time (and thus the cost) for the assay.

NEUROFIT proposes a cost-effective MK-801 based screening assay in the mouse T-maze alternation that is responsive to memory/learning enhancer drugs such as nicotine or donepezil.

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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