Rapid, sensitive, cost effective assay for the screening of cognitive enhancer compounds

Newsletter # 21

Animal models

Screening of cognitive enhancer compounds

NEUROFIT is a Contract Research Organisation (CRO) specialising in the evaluation of treatments for peripheral and central nervous system disorders.
NEUROFIT offers a long list of in vivo and in vitro validated methods and disease models for drug screening.

  • Age-associated memory impairment (AAMI) can be measured in the mouse by a reduced spontaneous alternation in the T-maze.

  • Mouse AAMI is reversed by Donepezil (Aricept) as well as by Nicotine, suggesting at least a dysfunction in the cholinergic system.

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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