Robust disease model for Relapsing-Remitting Multiple Sclerosis

Newsletter # 22

Animal models

Relapsing / Remitting Multiple Sclerosis (RR-MS) is the most frequent form of Multiple Sclerosis.

Neurofit offers a disease model for MS in the rat that mimics the RR-MS in human.

  • Integration of the Area Under each Curve used as a measure of Disease load (disease severity)
  • Highlights:

    Clear periods of remission and relapse
    Relapse phase as severe as in the first attack
    Robust assay to evaluate potential drug for the treatment of MS
    Provides dosing flexibility for the testing of different treatment strategies (e.g., preventive or curative treatment, treatment of relapse, etc...)
  • * : significantly different compared to untreated group

  • Dexamethasone therapy initiated at the peak of the first attack (blue bar) reduces by 80% the severity of the disease relapse.

    Dexamethasone therapy initiated at the first sign of second attack (red bar) reduces by 50% the severity of the disease relapse

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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