Animal model of Allergic contact dermatitis

Newsletter # 37



Animal models

Contact dermatitis is adverse cutaneous reaction resulting from direct contact with irritant or allergic substances. The skin reaction is an inflammation-driven process characterized by swollen itchy red rash or rough and dry skin.

Oxazolone-induced contact dermatitis (OCD) has been used as an animal model for screening / profiling of new drug therapies.

NEUROFIT has validated the model of OCD by topical application of approved drugs for eczema or psoriasis:

Apremilast
Calcipotriol
Dymethyl Fumarate
Tofacitinib
Clobetasol
Tacrolimus









  • Apremilast

    Ear swelling induced by oxazolone challenge in the rat (blue bar). Per os treatment with Apremilast markedly reduced the ear inflammation (red bars).


  • Calcipotriol

    Ear swelling induced by oxazolone challenge in the rat (blue bar).Topical application of Calcipotriol markedly reduced the ear inflammation (red bars).


  • Clobetasol

    Ear swelling induced by oxazolone challenge in the rat (blue bar).Topical application of Clobetasol markedly reduced the ear inflammation (red bars).



  • Dimethyl fumarate

    Ear swelling induced by oxazolone challenge in the rat (blue bar).Per os treatment with Dimethyl fumarate markedly reduced the ear inflammation (red bars).


  • Tacrolimus

    Ear swelling induced by oxazolone challenge in the rat (blue bar).Topical application of Tacrolimus markedly reduced the ear inflammation (red bars).


  • Tofacitinib

    Ear swelling induced by oxazolone challenge in the rat (blue bar).Per os treatment with Tofacitinib markedly reduced the ear inflammation (red bars).



NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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