Animal model of Allergic contact dermatitis

Newsletter # 37



Animal models

Contact dermatitis is adverse cutaneous reaction resulting from direct contact with irritant or allergic substances. The skin reaction is an inflammation-driven process characterized by swollen itchy red rash or rough and dry skin.

Oxazolone-induced contact dermatitis (OCD) has been used as an animal model for screening / profiling of new drug therapies.

NEUROFIT has validated the model of OCD by topical application of approved drugs for eczema or psoriasis:

Apremilast
Calcipotriol
Dymethyl Fumarate
Tofacitinib
Clobetasol
Tacrolimus









  • Apremilast

    Ear swelling induced by oxazolone challenge in the rat (blue bar). Per os treatment with Apremilast markedly reduced the ear inflammation (red bars).


  • Calcipotriol

    Ear swelling induced by oxazolone challenge in the rat (blue bar).Topical application of Calcipotriol markedly reduced the ear inflammation (red bars).


  • Clobetasol

    Ear swelling induced by oxazolone challenge in the rat (blue bar).Topical application of Clobetasol markedly reduced the ear inflammation (red bars).


  • Dimethyl fumarate

    Ear swelling induced by oxazolone challenge in the rat (blue bar).Per os treatment with Dimethyl fumarate markedly reduced the ear inflammation (red bars).


  • Tacrolimus

    Ear swelling induced by oxazolone challenge in the rat (blue bar).Topical application of Tacrolimus markedly reduced the ear inflammation (red bars).


  • Tofacitinib

    Ear swelling induced by oxazolone challenge in the rat (blue bar).Per os treatment with Tofacitinib markedly reduced the ear inflammation (red bars).


NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

If you need further information, please do not hesitate to contact us, we will reply within few days. Custom protocol

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