Newsletter # 43
Current animal models for ADHD feature psychomotor behavior impairments (impulsivity and hyperactivity) but do not always favorably respond to the psychostimulant drugs used for the treatment of ADHD.
The model implements pharmacological alteration of central cholinergic system implicated in ADHD pathology
Graph showing the beneficial effect of different doses of :
Methylphenidate (Ritalin ®), Amphetamine (Adderall ®) and Atomoxetine (Strattera ®) on induced cognitive dysfunction in mice.
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References: 1.Central nicotinic cholinergic systems: A role in the cognitive dysfunction in Attention-Deficit / Hyperactivity Disorder? Behavioural Brain Research 175 (2006) 201-211 2.Decreased binding capacity (Bmax) of muscarinic acetylcholine receptors in fibroblasts from boys with attention-deficit/hyperactivity disorder (ADHD). ADHD Atten Def Hyp Disord (2013) 5:267-271