Newsletter # 53
The Neurofit model of panic anxiety is performed in the rat challenged with CCK-4 and monitored in the Elevated Plus Maze. In line with the clinical finding, benzodiazepines restore the panic anxiety status of CCK-4 rats to the level of control animals.
*, p < 0.05, as compared to the placebo treatment
CCK-4 injection made the animals anxious as shown by the significantly reduced time spent (or number of entries) into the open arms of the maze.
In animals treated with Diazepam, the effects of CCK-4 were reversed and their performance was restored to the level of the control animals.