Human iPSC-derived Neurons

Newsletter # 54





Cellular models

Synapse loss and dendritic atrophy are common in psychiatric and neurodegenerative disorders and they are strongly correlated with cognitive decline. For example, synaptic loss in the hippocampus or cortex is an early and invariant feature of Alzheimer's disease.
The role of synaptic and dendritic pathology in diseases affecting the CNS highlights the importance of drug discovery strategies to promote dendrite formation and growth.

NEUROFIT offers Human iPSC Neurons-based screening to evaluate the capability of test compound to promote dendrite formation and growth.

Fast turn-around - Highly reproducible - Cost-effective



Neuronal cytoplasm is circled in blue, neurites are outlined in purple, branch point is indicated by a orange dot and red circles represent excluded objects

Example of data obtained with Amitriptiline (antidepressant drug).


  • Amitriptyline (Elavil) is tricyclic antidepressant (TCA) used to treat major depressive disorders.


Example of data obtained with Memantine (Alzheimer's drug).


  • Memantine is used for treating Alzheimer-type dementia. Memantine is an (NMDA)-receptor antagonist. Memantine works by blocking excess activity of glutamate.

More compounds

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

If you need further information, please do not hesitate to contact us, we will reply within few days. Custom protocol

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