Animal model of inflammation-induced cognitive decline

Newsletter # 55



Animal drug screening model

The inflammatory hypothesis of cognitive aging and neurodegeneration has received considerable attention. Indeed, several lines of evidence indicate positive association between inflammation and age-related cognitive decline and thus support the potential role of inflammation in the risk of dementia.
NEUROFIT offers a translational in vivo model of inflammation-induced cognitive deficit. Inflammation is produced in mice by single administration of a non-septic dose of LPS. The model has proved to be useful in demonstrating the clinical effect of drugs or compounds of different mechanisms.

The examples below show the amelioration of the cognitive function of LPS-mice by drugs used in humans for the treatment of Alzheimer's disease.

  • Cognitive performance is assessed as the level of spontaneous and continuous alternation in the T-maze.

    A lower alternation score represents lower cognitive performance.


    CSA : Continuous and Spontaneous Alternation.



  • *** , statistically significant as compared to the Placebo condition


    Memantine : Alzheimer's disease medication acting on the glutamatergic system by blocking NMDA receptors.


  • *, *** , statistically significant as compared to the Placebo condition


    Ibuprofen : Anti-inflammatory drug. People treated with Ibuprofen for inflammatory conditions are reported to have lower rates of Alzheimer's disease.


NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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