Newsletter # 55
Animal drug screening model
NEUROFIT offers a translational in vivo model of inflammation-induced cognitive deficit. Inflammation is produced in mice by single administration of a non-septic dose of LPS. The model has proved to be useful in demonstrating the clinical effect of drugs or compounds of different mechanisms.
Cognitive performance is assessed as the level of spontaneous and continuous alternation in the T-maze.
A lower alternation score represents lower cognitive performance.
CSA : Continuous and Spontaneous Alternation.
*** , statistically significant as compared to the Placebo condition
Memantine :Alzheimer's disease medication acting on the glutamatergic system by blocking NMDA receptors.
*, *** , statistically significant as compared to the Placebo condition
Ibuprofen :Anti-inflammatory drug. People treated with Ibuprofen for inflammatory conditions are reported to have lower rates of Alzheimer's disease.