The pathogenic role of amyloid beta (Aβ) in various dementia related disorders such Alzheimer’s diseases (AD) is well accepted. Compelling evidences indicate the extracellular accumulation of Aβ is already present at the asymptomatic (preclinical) stage of AD. Thus, early intervention to prevent Aβ accumulation appear as attractive strategies for AD treatment.
NEUROFIT has developed a functional neuronal assay that accumulates extracellular Aβ. The system is tailored to assess the efficiency of Aβ lowering drugs such as BACE inhibitors. In parallel, the assay provides also information about the potential safety or neurotoxicity of the tested drug.