Alzheimer preclinical model for the evaluation of
cognitive-enhancing drugs: Memantine validation


Newsletter # 65

Animal models


The NMDA-receptor antagonist Memantine is a FDA-approved drug used to treat Alzheimer-type dementia, especially for patients who have a contraindication to acetylcholinesterase inhibitors. Although clinical evidences support the cognitive-enhancing effect of memantine, the effect in rodents is not very clear yet and results reported so far are not always consistent.

Here we provide a clear-cut result that validate the cognitive enhancing effect of memantine in a rodent model of Alzheimer's disease.

  • Memantine reverses β-amyloid-induced cognitive deficits




  • In this Rat model, cognitive deficit is induced by Intracerebroventricular injection of β-amyloid.

    Treatment with Memantine fully reverses the cognitive deficit.


    This model provides a robust preclinical assay for evaluation of cognitive-enhancing drugs, especially in Alzheimer-type dementia.


NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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