cognitive-enhancing drugs: Memantine validation
Newsletter # 65
Memantine reverses β-amyloid-induced cognitive deficits
■In this Rat model, cognitive deficit is induced by Intracerebroventricular injection of β-amyloid.
■Treatment with Memantine fully reverses the cognitive deficit.
■This model provides a robust preclinical assay for evaluation of cognitive-enhancing drugs, especially in Alzheimer-type dementia.