Newsletter # 66
Venlafaxine reverses natural compulsive behaviors
of rodents placed in a novel environments
■Treatment with Venlafaxine reverses the burying behavior of mice placed in a novel environment.
■Marble burying test is a known and validated paradigm to test the anti-depressant/anxiolytic effect of drug treatments in mouse.
■Indeed, this test model has proved to be sensitive to the anxiolytics such as benzodiazepines, and to anti-depressants such as Fluoxetine (SSRI).