Evaluation of anti-depressant and/or anxiolytic drugs:
Venlafaxine validation

Newsletter # 66

Animal models

Venlafaxine (e.g. Effexor, Lanvexin, Viepax or Trevilor) is a psychoactive drug used for the treatment of depression or anxiety disorders. It is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.

Here we provide a clear-cut result that validates the effect of Venlafaxine in a behavioral test routinely used at NEUROFIT to test predictive value for anti-depressant and/or anxiolytic drugs.

  • Venlafaxine reverses natural compulsive behaviors
    of rodents placed in a novel environments

  • Treatment with Venlafaxine reverses the burying behavior of mice placed in a novel environment.

    Marble burying test is a known and validated paradigm to test the anti-depressant/anxiolytic effect of drug treatments in mouse.

    Indeed, this test model has proved to be sensitive to the anxiolytics such as benzodiazepines, and to anti-depressants such as Fluoxetine (SSRI).

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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