Ginkgo biloba improves cognitive deficit and anxiety like-behavior in mice

Newsletter # 91



Animal models

Ginkgo biloba is mainly acclaimed for its effectiveness in maintaining cognitive capacity and reducing anxiety symptoms in elderly persons. Indeed, the outcomes of a 20-year follow-up population-based study and trials in patients with tinnitus and dementia seems to support the above assumption. 1 , 2.
At Neurofit, one single administration of Ginkgo biloba extract 16h prior to the testing is sufficient to improve cognitive deficit in the mice. Furthermore, a reduced anxiety behavior is observed after 1-week daily treatment. Mechanisms of action may include free radical scavenging, neurotransmitter/receptor modulation and antiplatelet properties.

1: doi: 10.1371/journal.pone.0052755
2: doi: 10.3390/jcm10143151

  • NEUROFIT website

    Cognitive performance assessed in the T-maze alternation task

    Left panel: The graph shows the cognitive performance of mice as measured by their spontaneous alternation in the T-maze. Scopolamine-induced deficit is evidenced by the decrease in the spontaneous alternation of mice (white vs black column), which reflects a repetitive insistence (stereotypy) on the visit of the same arm of the T-maze.
    The administration of Ginkgo biloba dose-dependently improves the spontaneous alternation performance of scopolamine mice, hence their cognitive ability (Black vs red columns).



  • NEUROFIT website

    Anxiety-like behavior assessed in the
    Elevated Plus-Maze test

    Right panel : The graph shows the anxiety status of mice in the Elevated Plus Maze test (EPM). It is a commonly used test to evaluate the anxiety-like behavior of mice in one single trial. The test is based on an approach/avoidance conflict between the drive to explore novel areas and the aversion to brightly lit, open spaces. Hence, increase in the time spent in the anxiogenic area (open arms) during the trial is an indication of potential anxiolytic effect of test compounds.

    Herein, the treatment of mice with Ginkgo biloba induces a dose-dependent increase in the time spent in the open arms suggesting a reduced anxiety status of mice.



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