Resveratrol reverses inflammation-induced cognitive decline

Newsletter # 92

In vivo studies

Resveratrol, a polyphenol naturally present especially in red wines and grapes is among phytochemicals investigated to explain the French Paradox, i.e., a relatively low rate of cardiovascular disease in the french population, despite a high intake of saturated fat. There are compelling evidences showing the antioxidant, anti-inflammatory and phosphodiesterase inhibitory effects of resveratrol.
Through these mechanisms, plethora of health benefits have been proposed for resveratrol including cardioprotective, antithrombotic, anticarcinogenic, and neuroprotective properties

Some number of clinical investigations showed that resveratrol supplementation can bring beneficial effects to patients with mild cognitive impairment (MCI) or Alzheimer's disease (AD)
(reviewed in DOI: 10.1089/jmf.2021.0084).

  • ***, p ≤ 0.001 significantly different as compared
    to LPS / Vehicle group (n = 10 mice per group)
  • At Neurofit, 1 week (once daily) treatment with resveratrol fully restores inflammation-based cognitive deficit in the mouse (see below).
    This preclinical finding further supports the potential therapeutic benefits of resveratrol in the brain disease conditions involving inflammation such as AD.

    The graph shows a marked reduction in the level of spontaneous alternation of LPS-mice (red column) during the T-maze task as compared to that of control mice (grey column). The decrease in the alternation reflects stereotypic and repetitive behavior, a common symptoms in dementia patients.
    (DOI: 10.1177/1533317513481094).

    The treatment of LPS-mice with Resveratrol (green column) significantly increases the alternation performance of LPS-mice. Resveratrol was administrated at 10 mg/kg once daily for 7 days.

  • You could also be interested in cellular model of brain inflammation in rat glia-mesencephalic neurons culture

    If you are interested in these models and would like to learn more about them or other models and assays available at NEUROFIT, please visit our website : THERAPEUTIC AREA or TESTS sections

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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