Newsletter # 32
Intra-cerebroventricular (i.c.v.) injections of fibrillated Amyloid-β (Aβ) in rats is associated with neuropathological features of AD. Faster and cost-effective than transgenic mice, this model is tailored to accelerate and aid drug discovery in the treatment of AD.
Effect of subchronic and single treatment with donepezil on the passive avoidance performance of i.c.v. Aβ-injected rats (2 weeks post-i.c.v. injection)
i.c.v. injection of Aβ impairs the acquisition of passive avoidance task.
Subchronic but not acute donepezil prevents this impairment.
i.c.v. injection of Aβ disrupts the retention of passive avoidance.
Subchronic but not acute donepezil enhances the retention of passive avoidance in i.c.v. Aβ-injected rats.
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