Rodent model of nerve-axonal regeneration - Newsletter - Preclinical Contract Research Organization (CRO) for CNS and PNS disorders

Translational model of Multiple Sclerosis - Remittance and disease relapse

Newsletter # 59

Animal models

Multiple Sclerosis (MS) is a chronic disease of the central nervous system, which predominantly affects young adults. A few medications can be used to treat the symptoms but they have limited efficacy or safety. Thus, the search for new and more effective treatments for MS remains an area of great focus.

NEUROFIT offers several preclinical models relevant for drug testing in MS. The rat model highlighted herein is translatable to clinical setting of Relapsing/Remitting Multiple Sclerosis (RR-MS). Similarly to MS patients, affected rats show dexamethasone-sensitive disease relapse.

NEUROFIT offers several specific and validated models of Multiple Sclerosis. Here we propose the proof of internal validation of Relapsing/Remitting Multiple Sclerosis (RR-MS) model in the rat.

• Periods of remission and relapse, as described in human MS patients.
• Relapse phase as severe as in the first attack in untreated RR-MS subjects.
• Dexamethasone therapy reduces the severity of the disease relapse.
• The severity of the disease relapse has been proved to be dependant of the compound administration period.

The RR-MS model proposed by Neurofit provides an interesting and robust assay to evaluate the effect of your compounds on the disease relapse as it mimics the remittance and disease relapse in as in MS patients. Others in-vivo and in-vitro specific Multiple Sclerosis models are also available.
- NEUROFIT, your worldwide preferred service provider of validated in-vivo and in-vitro diseases models for drug screening or for evaluating the mechanism of action of your compounds. Please, do not hesitate to consult our website for more information about our animal and neurocellular models, or to consult us directly for a personalized and privileged accompanying on your issues.

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

If you need further information, please do not hesitate to contact us, we will reply within few days. Custom protocol

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Newsletter # 59

Animal models

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NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.