Translational model of DELAYED-TYPE HYPERSENSITIVITY

Newsletter # 60

Animal models


Delayed-Type Hypersensitivity (DTH) is an important in vivo manifestation of cell-mediated immunity. The development of DTH elicited by prior exposure to antigens involves T lymphocyte function. The DTH response provides thus an in-vivo window of T-cell response and serves as a convenient model to determine the efficacy of immunomodulators or immunosuppressants.

The rat model highlighted herein is translatable to the Delayed-Type Hypersensitivity reaction in human characterized by erythema and oedema at the site of antigen injection.



  • Ear swelling as measured by an increased pinna thickness is a robust read-out to quantify the DTH reaction in rat.

    Immunosuppressants such as dexamethasone or cyclophosphamide suppress this immune response.


NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

If you need further information, please do not hesitate to contact us.
On a regular basis we distribute newsletters with scientific information on our research services. If you wish to receive these, please sign up on our mailing list:


e-mail :


Field of interrest :