Newsletter # 60

Animal models

Delayed-Type Hypersensitivity (DTH) is an important in vivo manifestation of cell-mediated immunity. The development of DTH elicited by prior exposure to antigens involves T lymphocyte function. The DTH response provides thus an in-vivo window of T-cell response and serves as a convenient model to determine the efficacy of immunomodulators or immunosuppressants.

The rat model highlighted herein is translatable to the Delayed-Type Hypersensitivity reaction in human characterized by erythema and oedema at the site of antigen injection.

  • Ear swelling as measured by an increased pinna thickness is a robust read-out to quantify the DTH reaction in rat.

    Immunosuppressants such as dexamethasone or cyclophosphamide suppress this immune response.

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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